It is a common practice to write one generic resume and send it to as many different companies as possible. But this leads to no replies because resume becomes inaccurate and irrelevant.
Instead of sending generic resumes to hundreds of companies, concentrate on the ones that appeal to you the most. What industries do you like? What companies attract your attention? Do you like small startups or big corporations? Find companies that satisfy your career goal.
Find five great companies per day and target your resume for each one of your chosen job positions. The next day find five more. This strategy will land you much better results!
Learn about companies and spend a big portion of your time reading. In just half an hour, you can get so much valuable information, know company's goals, market capital, competitors, innovations and important news.
Don't start writing your resume (and cover letter) without analyzing particular company and its interaction with the industry. Too many people write generic resumes and as a result, they receive zero calls.
After all, your resume needs to target a specific job position and it has to reflect the chosen company and the position. Only then you will have the highest chances to land the job interview.